上海交通大學醫(yī)學院附屬瑞金醫(yī)院前沿治療研究中心現招聘博士后研究人員。本中心由首席科學家Michael Shepard教授領銜，依托瑞金醫(yī)院豐富的臨床資源和雄厚的科研實力，聚焦腫瘤、炎癥與自身免疫性疾病的前沿治療研究，致力于推動治療模式的創(chuàng)新。我們擁有多學科專家團隊、國際一流的研究設施與實驗平臺，為高水平科學研究提供堅實基礎。
Michael Shepard教授簡介
Michael Shepard教授是國際公認的生物技術創(chuàng)新者和癌癥研究先驅。作為前沿治療研究中心首席科學家兼腫瘤生物學顧問，他開創(chuàng)了多個革命性療法：作為赫賽?。ㄇ字閱慰梗┑暮诵陌l(fā)明人之一，其研發(fā)的HER2陽性乳腺癌療法已惠及全球逾50萬患者；他率先提出"泛HER"抑制概念、酶催化治療技術（ECTA），并將首個腺病毒基因療法推進至臨床試驗階段，促成近期獲批用于高危膀胱癌的非復制型腺病毒基因療法Adstiladrin。目前，他正將成功的癌癥治療模式拓展至炎癥與自身免疫性疾病領域。其卓越貢獻榮獲2019年拉斯克-迪貝基臨床醫(yī)學研究獎、2007年沃倫?阿爾珀特獎等國際殊榮。Shepard教授擁有50余項生物治療與診斷專利，多次在權威期刊發(fā)表論著，并積極通過學術講座與合作項目培育青年科學家。他現任瑞金醫(yī)院、達蒙?魯尼恩癌癥研究基金會及俄勒岡健康科學大學騎士研究所特邀專家，在科研與教育領域持續(xù)發(fā)揮引領作用。
博士后研究項目：
本項目致力于開發(fā)針對急性髓系白血病（AML）的新型多特異性抗體，旨在通過靶向抑制更廣泛的AML細胞群體，且具有特異性增強的下一代抗體，以突破當前AML治療的局限。入選的博士后將參與設計，研發(fā)、功能驗證等創(chuàng)新研究。
核心職責：
? 設計、構建、表達新型多特異性抗體
? 采用多種純化技術（親和、離子交換、分子篩等）進行抗體純化與優(yōu)化
? 通過生化與生物物理方法（SDS-PAGE、SEC-HPLC、BLI/SPR親和力測定）檢測抗體純度與特性
? 利用多種細胞（AML細胞、效應細胞等）和多種平臺技術（流式細胞術、ELISA）對多特異抗體展開功能及細胞毒性評估
? 分析實驗數據、完善研究記錄，并定期在實驗室會議與學術會議上匯報成果
? 撰寫優(yōu)質學術論文
任職要求：
? 近期或即將獲得生物化學、分子生物學、免疫學、生物工程等相
? 具備分子生物學技術實戰(zhàn)經驗（PCR、克隆、質粒設計與制備）
? 擁有蛋白質表達與純化（?KTA SEC-FPLC）的經驗
? 熟練掌握細胞實驗技術（細胞培養(yǎng)、轉染、流式細胞術、功能實驗）
? 以第一作者在同行評審期刊發(fā)表過多篇論文
? 具有獨立科研與解決問題能力
? 團隊協(xié)作能力
? 中英文雙語工作能力（書面與口語）
我們提供：
? 具有競爭力的薪酬與完善福利待遇（根據資歷核定）
? 對博士后的職業(yè)發(fā)展提供幫助
? 尖端核心設施支持（流式細胞儀、共聚焦顯微鏡、Biacore、AKTA、動物模型與臨床樣本平臺）
? 跨學科、支持性、動態(tài)化的科研環(huán)境
? 學術交流與會議參會機會
申請方式：
請將以下材料合并為PDF文件發(fā)送至郵箱地址：juan2025SH@outlook.com，ruijinboshihou@163.com，郵件主題注明"博士后申請+高校人才網"：【快捷投遞：點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】
1. Cover Letter：闡述研究方向、職業(yè)規(guī)劃及崗位適配性
2. 詳細簡歷（含出版物列表）
3. 三位推薦人的聯(lián)系方式
Job Announcement: Postdoctoral Fellow – Multispecific Antibody Therapeutics
Introduction of Research Platform
The Frontiers in
Introduction of Professor Michael Shepard
Professor Michael Shepard is a globally
recognized innovator in biotechnology and a pioneering figure in cancer
research. As the Chief Scientist of the Frontiers in
Post-doctoral Project Description:
We are seeking a highly motivated and creative Postdoctoral Fellow to join an innovative research project focused on developing novel multi-specific antibodies for Acute Myeloid Leukemia (AML). This project aims to overcome current limitations in immunotherapy by engineering next-generation antibodies capable of targeting broader AML cell populations with enhanced selectivity. The successful candidate will have the unique opportunity to drive this project from initial computational design through in vitro characterization and preclinical validation.
Key Responsibilities:
? Design, construct, and express novel multispecific antibodies using mammalian expression systems (e.g., HEK293, CHO cells)
? Optimize and perform antibody purification using various chromatographic techniques (affinity, ion-exchange, size-exclusion)
? Characterize antibody properties using biochemical and biophysical methods (SDS-PAGE, SEC-HPLC, BLI/SPR for affinity measurements)
? Evaluate antibody functionality through comprehensive in vitro assays including binding assessments (flow cytometry, ELISA) and cytotoxicity studies using primary AML cells and effector cells
? Analyze experimental data, maintain detailed documentation, and present findings at lab meetings and scientific conferences
? Prepare manuscripts for publication in high-impact journals
Required Qualifications:
? Recently awarded or upcoming Ph.D. in Biochemistry, Molecular Biology, Immunology, Bioengineering, or related field
? Extensive hands-on experience with molecular biology techniques (PCR, cloning, plasmid design and preparation)
? Demonstrated expertise in protein expression (transient/stable transfection) and purification (?KTA FPLC systems)
? Proficiency with cell-based assays (cell culture, transfection, flow cytometry, functional assays)
? Strong publication record with first-author papers in peer-reviewed journals
? Excellent problem-solving abilities and capacity for independent research
? Ability to work effectively in a collaborative team environment
? Fluency in both English and Chinese (written and verbal)
We Offer:
? Competitive salary and comprehensive benefits package commensurate with experience
? Dedicated mentorship focused on career development in academia or industry
? Access to state-of-the-art core facilities (flow cytometry, microscopy, Biacore, AKTA, animal models, and clinical samples)
? Dynamic, supportive, and interdisciplinary research environment
? Opportunities for professional networking and conference travel
Application Process:
Please submit the following materials as a single PDF file to Email Address：juan2025SH@outlook.com，ruijinboshihou@163.com with the subject line "Postdoc Application: Cover letter outlining research interests, career goals, and specific qualifications for this position
1.Current CV including publication list
2.Contact information for three professional references
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