Dr. You is currently an Investigator at
CIMR and Associate Director of the Chinese Institute for Cancer Research within
CIMR. Prior to joining CIMR in 2025, he was a tenured professor at Washington University
in St. Louis, School of Medicine.
The You lab at CIMR investigates the molecular mechanisms of genome
maintenance, RNA surveillance, and innate immunity, with the overarching goal
of advancing cancer and autoimmune disease treatment. We integrate cell
biology, structural biology, drug screening, and animal models to drive these
studies.
Lab website：
https://www.cimrbj.ac.cn/en/channel/1972181105834594304.html
Major Research
Projects
The laboratory focuses on the following
key research areas:
a.Intersection of DNA/RNA surveillance
with innate immunity
b.Emerging roles of ions and ion channels
in regulating cGAS/STING innate immune signaling
c.Therapeutic targeting of the TRPV2-STING
axis in cancer and autoimmunity
d.Exploiting NMD vulnerability in
spliceosome-mutant cancers
Major
Contributions
1.Discovered a novel cytosolic
DNA-elicited, Ca2+-mediated signaling pathway that safeguards DNA replication
forks to preserve genome stability. (Mol Cell, 2019; Mol Cell 2023; Nat Commun,
2024)
2.Uncovered a novel interplay on the
endoplasmic reticulum between the ion channel TRPV2 and the innate immune
sensor STING, revealing a new mechanism for the co-regulation of Ca2+ dynamics
and immune activation. (Mol Cell 2023; Cell Rep, accepted)
3.Pioneered the development of NMD
reporter systems, enabling the identification of novel NMD inhibitors and
genetic regulators, and demonstrated that NMD is modulated by intracellular
Ca2+ and persistent DNA damage (Nat Med 2014; JBC 2017)
4.Established NMD as a promising
therapeutic target for cancers harboring spliceosome mutations (Cancer Res
2021, Cancer Res, in review)
Representative
Publications
Nature Communications, 2024, doi:
10.1038/s41467-024-48988-6. PMID: 38816425.
Molecular Cell, 2023, doi:
10.1016/j.molcel.2022.12.034. PMID: 36696898.
Molecular Cell, 2019, doi:
10.1016/j.molcel.2019.04.003. PMID: 31053472.
Cancer Research, 2021, doi:
10.1158/0008-5472.CAN-20-4016. PMID: 34215620.
Nature Medicine, 2014, doi:
10.1038/nm.3620. PMID: 25064126
